Lucrarea :
GUT MICROBIOTA AND ALZHEIMER’S DISEASE
Major Gheorghe Giurgiu1, Prof Dr Med Manole Cojocaru2, SciRes I, EuSpLM
1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania
deniplant@gmail.com; Telephone: +40744827881
https://orcid.org/0000-0002-5449-2712
2Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
Romanian Academy of Scientists
cojocaru.manole@gmail.com; Telephone: +40723326663
https://orcid.org/0000-0002-7192-7490
Alzheimer’s disease is a most common neurodegenerative disorder, which associates with impaired cognition.
Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior.
Antibioticscan induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of Alzheimer’s disease.
The increased permeability of intestine and blood-brain barrier induced by gut microbiota disturbance will increase the incidence of neurodegeneration disorders.
Imbalances in the gut microbiota can be also associated with the neurodegeneration.
There is increasing interest in the role of the peripheral immune system in Alzheimer’s disease pathology.
We are currently assessing whether indoles can also stimulate formation of neurons in Alzheimer’s disease
Disturbances along the brain-gut-microbiota axis may significantly contribute to the pathogenesis of neurodegenerative disorders.
Alterations in the gut microbiota composition induce increased permeability of the gut barrier and immune activation leading to systemic inflammation, which in turn may impair the blood-brain barrier and promote neuroinflammation, neural injury, and ultimately neurodegeneration.
Nutrition is known to play an important role in the pathogenesis of Alzheimer’s disease.
In addition, the use of nutraceuticals can be part of a comprehensive approach to delay neurodegeneration
Objective
Modification of the gut microbiota composition by nutraceuticals may create new preventive and therapeutic options in Alzheimer’s disease.
To arrive at these observations, the authors examined how Polenoplasmin and diet delay neurodegeneration
Materials and methods
Alzheimer’s disease may begin in the gut, and is closely related to the imbalance of gut microbiota.
We are currently assessing whether indoles can also stimulate formation of neurons in Alzheimer’s disease
Gheorghe Giurgiu created the product Polenoplasmin under the license of the Deniplant brand owner Gheorghe Giurgiu.
Polenoplasmin acts as a modulator of the gut microbiome, is a natural regenerator of the nerve cell.
These studies indicate that gut microbiota modulate inflammatory response.
These findings bring us closer to the possibility of novel treatment options to slow down memory loss, which is a common problem with aging and neurodegenerative diseases including but not limited to Alzheimer’s disease
Polenoplasmin is a nutraceutical (food with a dual role of nutrition and health) for nerve regeneration.
Polenoplasmin is not medically certified, but its components have scientifically proven healing qualities.
It contains freeze-dried pollen from Deniplant plants, carob seed powder, brewer’s yeast.Combining them we managed to obtain a product with a wide spectrum of action without side effects or side effects.
The components themselves are foods that we can eat daily. That’s why Polenoplasmin has the slogan „Eat and heal”.
These findings bring us closer to the possibility of novel treatment options to slow down memory loss, which is a common problem with aging and neurodegenerative diseases including but not limited to Alzheimer’s disease.
These include drugs to mimic the action of indoles to stimulate the production of new neurons in the hippocampus or to replace neurons damaged by stroke, as well as designing dietary intervention using food products enriched with indoles as a preventive measure to slow down aging.
Results
It has now been shown that microbiota affects brain functions through various metabolites with potentially positive or, conversely, toxic properties.
The immune system has a prominent role in Alzheimer’s disease pathogenesis with both innate and adaptive immunity in the central nervous system.
Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for Alzheimer’s disease.
There is a strong link between Alzheimer’s disease and chronic inflammation.
Due to its composition rich in antioxidants, anti-inflammatory agents, amino acids, minerals and natural vitamins, neuroregenerative molecules, the product Polenoplasmin offers various possibilities to balance the processes that take place in the nerve cell.
Being a food, it is not medically certified, but its components have scientifically proven healing qualities
Conclusion
Alzheimer’s disease is a neurodegenerative disorder characterized by a progressive decline in memory and thinking severe enough to interfere with daily life.
Alzheimer’s disease may begin in the gut, and is closely related to the imbalance of gut microbiota.
Modification of the gut microbiota composition by nutraceuticals may create new preventive and therapeutic options in Alzheimer’s disease.
Existing evidence suggests that dietary lifestyle changes may affect cognitive function.This study is another intriguing piece of the puzzle highlighting the importance of lifestyle factors and diet.
References
Hu X, Wang T, Jin F. Alzheimer’s disease and gut microbiota. Sci. China Life Sci. 2016, 59, 1006-23.
Jiang C, Li G, Huang P, Liu Z, Zhao B.The Gut Microbiota and Alzheimer’s Disease.J Alzheimers Dis. 2017;58(1):1-15.
Szablewski L.Human Gut Microbiota in Health and Alzheimer’s Disease.J Alzheimers Dis. 2018;62(2):549-60.
Kesika P, Suganthy N, Sivamaruthi BS, Chaiyasut C.Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer’s disease.Life Sci. 2021;264:118627.
Angelucci F, Cechova K, Amlerova J, Hort J.Antibiotics, gut microbiota, and Alzheimer’s disease.J Neuroinflammation. 2019;16(1):108.
Varesi A, Pierella E, Romeo M, et al. The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment.Nutrients. 2022;14(3):668.