Lucrarea:
A LINK BETWEEN GUT MICROBIOTA AND
ALZHEIMER’S DISEASE: IMPACT OF NEUROPOLEN
Major Gheorghe Giurgiu1, Prof Dr Med Manole Cojocaru2, SciRes I, EuSpLM
1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania
deniplant@gmail.com; Telephone: +40744827881
https://orcid.org/0000-0002-5449-2712
2Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
Academy of Romanian Scientists
cojocaru.manole@gmail.com; Telephone: +40723326663
https://orcid.org/0000-0002-7192-7490
Alzheimer’s disease is a most common neurodegenerative disorder, which associates with impaired cognition.
Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior.
Antibioticscan induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of Alzheimer’s disease.
The increased permeability of intestine and blood-brain barrier induced by gut microbiota disturbance will increase the incidence of neurodegeneration disorders
Imbalances in the gut microbiota can be also associated with the neurodegeneration.
There is increasing interest in the role of the peripheral immune system in Alzheimer’s disease pathology.
We are currently assessing whether indoles can also stimulate formation of neurons in Alzheimer’s disease.
Disturbances along the brain-gut-microbiota axis may significantly contribute to the pathogenesis of neurodegenerative disorders.
Alterations in the gut microbiota composition induce increased permeability of the gut barrier and immune activation leading to systemic inflammation, which in turn may impair the blood-brain barrier and promote neuroinflammation, neural injury, and ultimately neurodegeneration.
Nutrition is known to play an important role in the pathogenesis of Alzheimer’s disease.
In addition, the use of nutraceuticals can be part of a comprehensive approach to delay neurodegeneration.
Objective
Modification of the gut microbiota composition by nutraceuticals may create new preventive and therapeutic options in Alzheimer’s disease.
To arrive at these observations, the authors examined how Neuropolen and diet delay neurodegeneration
Materials and methods
Alzheimer’s disease may begin in the gut, and is closely related to the imbalance of gut microbiota.
We are currently assessing whether indoles can also stimulate formation of neurons in Alzheimer’s disease
Neuropolen is a nutraceutical (food with a dual role of nutrition and health) for the regeneration of destroyed nerve cells.
The use of the components of Neuropolen in the solution of human medical conditions was made long before the appearance of the product under this name.
Neuropolen is a natural neuroregenerator of the nerve cell.
Neuropolen contains freeze-dried pollen from Deniplant plants, cocoa bean and carob seed powder, brewer’s yeast. Combining them we managed to obtain a product with a wide spectrum of action without side effects or side effects. The components themselves are foods that we can eat daily. That’s why Neuropolen has the slogan „Eat and heal”
Results
It has now been shown that microbiota affects brain functions through various metabolites with potentially positive or, conversely, toxic properties.
The immune system has a prominent role in Alzheimer’s disease pathogenesis with both innate and adaptive immunity in the central nervous system.
Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for Alzheimer’s disease.
There is a strong link between Alzheimer’s disease and chronic inflammation.
Due to its composition rich in antioxidants, anti-inflammatory agents, amino acids, minerals and natural vitamins, neuroregenerative molecules, the product Neuropolen offers various possibilities to balance the processes that take place in the nerve cell.
Being a food, it is not medically certified, but its components have scientifically proven healing qualities.
Conclusion
Alzheimer’s disease is a neurodegenerative disorder characterized by a progressive decline in memory and thinking severe enough to interfere with daily life.
Alzheimer’s disease may begin in the gut, and is closely related to the imbalance of gut microbiota.
Modification of the gut microbiota composition by nutraceuticals may create new preventive and therapeutic options in Alzheimer’s disease.
Existing evidence suggests that dietary lifestyle changes may affect cognitive function.This study is another intriguing piece of the puzzle highlighting the importance of lifestyle factors and diet.
References
Hu X, Wang T, Jin F. Alzheimer’s disease and gut microbiota. Sci. China Life Sci. 2016, 59, 1006-23.
Jiang C, Li G, Huang P, Liu Z, Zhao B.The Gut Microbiota and Alzheimer’s Disease.J Alzheimers Dis. 2017;58(1):1-15.
Szablewski L.Human Gut Microbiota in Health and Alzheimer’s Disease.J Alzheimers Dis. 2018;62(2):549-60.
Kesika P, Suganthy N, Sivamaruthi BS, Chaiyasut C.Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer’s disease.Life Sci. 2021;264:118627.
Angelucci F, Cechova K, Amlerova J, Hort J.Antibiotics, gut microbiota, and Alzheimer’s disease.J Neuroinflammation. 2019;16(1):108.
Varesi A, Pierella E, Romeo M, et al. The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment.Nutrients. 2022;14(3):668.